PedAM
Pediatric Disease Annotations & Medicines
| Disease | lynch syndrome |
| Phenotype | C0009402|colorectal cancer |
| Sentences | 44 |
| PubMedID- 20010342 | Prevention of metachronous colorectal cancer in patients with lynch syndrome. |
| PubMedID- 25794514 | Approximately 3% of colorectal cancers are associated with lynch syndrome. |
| PubMedID- 23733757 | Purpose: molecular screening techniques are available to identify hereditary lynch syndrome in people with newly diagnosed colorectal cancer (crc). |
| PubMedID- 26284327 | The lifetime risk of colorectal cancer for males with lynch syndrome generally is significantly higher and the age of first manifestation significantly earlier compared to females. |
| PubMedID- 26473097 | Testing for lynch syndrome in patients with newly-diagnosed colorectal cancer and their relatives. |
| PubMedID- 22262812 | colorectal cancers associated with lynch syndrome are characterized by deficient dna mismatch repair (mmr) function. |
| PubMedID- 20495877 | Magnetic resonance colonography for colorectal cancer screening in patients with lynch syndrome gene mutation. |
| PubMedID- 23245329 | Gain of material on chromosome 20q and loss on chromosome 18 significantly discriminated colorectal cancers associated with fcctx from lynch syndrome, which likely signifies different preferred tumourigenic pathways. |
| PubMedID- 24415879 | Epithelial-mesenchymal transition in colorectal cancer tissue of patients with lynch syndrome. |
| PubMedID- 25534380 | Short-term risk of colorectal cancer in individuals with lynch syndrome: a meta-analysis. |
| PubMedID- 22056658 | Interpretation of genetic testing for lynch syndrome in patients with putative familial colorectal cancer. |
| PubMedID- 21768580 | Strategies to identify the lynch syndrome among patients with colorectal cancer: a cost-effectiveness analysis. |
| PubMedID- 21743847 | The american college of gastroenterology found moderate quality evidence for their recommendation that colorectal cancer patients with lynch syndrome undergo colonoscopy every 2 years beginning at age 20-25 and then annually after age 40 [9]. |
| PubMedID- 20206180 | One to 2-year surveillance intervals reduce risk of colorectal cancer in families with lynch syndrome. |
| PubMedID- 20704743 | About 3% of all colorectal cancers is due to lynch syndrome, an autosomal dominant condition caused by germline mutations in one of the dna mismatch repair (mmr) genes, mlh1, msh2, msh6 and pms2 [1]. |
| PubMedID- 23598716 | Purpose: routine screening for evidence of dna mismatch repair abnormalities can identify colorectal cancer patients with lynch syndrome, but impact in usual care settings requires study. |
| PubMedID- 23470269 | Background: colorectal cancer (crc) associated with lynch syndrome usually presents at a relatively young age. |
| PubMedID- 25731324 | [effect of chemotherapy on the inoperable or recurrent colorectal cancers in patients with lynch syndrome]. |
| PubMedID- 22237445 | Implementing screening for lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting. |
| PubMedID- 25583420 | Relationship between smoking and multiple colorectal cancers in patients with japanese lynch syndrome: a cross-sectional study conducted by the japanese society for cancer of the colon and rectum. |
| PubMedID- 24225971 | Molecular tumor testing for lynch syndrome in patients with colorectal cancer. |
| PubMedID- 24759670 | Some colorectal cancers with lynch syndrome-like pedigrees remain mutation-negative in a dna mismatch repair (mmr) gene analysis [14]. |
| PubMedID- PMC3288925 | Msi is present in 80-85% of colorectal cancers associated with lynch syndrome. |
| PubMedID- PMC2876284 | This study analyzes precursor polyp burdens occurring within patients with msi-h colorectal cancers associated with lynch syndrome (ls) or those with a methylator pathway cancer phenotype. |
| PubMedID- 23787146 | To establish a diagnosis of lynch syndrome, every patient with colorectal cancer should undergo a detailed family history. |
| PubMedID- 23073952 | Identification of lynch syndrome among patients with colorectal cancer. |
| PubMedID- 22480969 | Background: recommended strategies to screen for lynch syndrome in colorectal cancer are not applied in daily practice and most of lynch cases remain undiagnosed. |
| PubMedID- 25213040 | Aim: colonic surveillance reduces the lifetime risk of colorectal cancer in patients with lynch syndrome (hereditary nonpolyposis colorectal cancer) from 60 to 80% to 10% and confers a 7-year survival advantage. |
| PubMedID- 25081898 | Background: recognising colorectal cancer (crc) patients with lynch syndrome (ls) can increase life expectancy of these patients and their close relatives. |
| PubMedID- 23508345 | The surgical management of the lynch syndrome patient with colorectal cancer needs to be individualized. |
| PubMedID- 26249337 | Lower prevalence of lynch syndrome in colorectal cancer patients in a japanese hospital-based population. |
| PubMedID- 23073955 | lynch syndrome in patients with colorectal cancer: finding the needle in the haystack. |
| PubMedID- 25754680 | Fertility after young-onset colorectal cancer: a study of subjects with lynch syndrome. |
| PubMedID- 24056992 | Some studies reported since publication of the egapp analysis have added to the evidence regarding clinical utility to the relatives of colorectal cancer patients diagnosed with lynch syndrome. |
| PubMedID- 25910169 | The objective of this project was to estimate the cost-utility of strategies to identify lynch syndrome in individuals with early-onset colorectal cancer in the nhs. |
| PubMedID- 19957108 | Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with lynch syndrome. |
| PubMedID- 25323653 | Applying public health screening criteria: how does universal newborn screening compare to universal tumor screening for lynch syndrome in adults with colorectal cancer. |
| PubMedID- 22411104 | Daily aspirin reduces colorectal cancer incidence in patients with lynch syndrome. |
| PubMedID- 22175017 | However, there have been fewer studies on endometrial cancer compared to colorectal cancer in patients with lynch syndrome. |
| PubMedID- 25142628 | The percentage of cancers revealed in 1st (2%) and 2nd degree (8%) relatives were increasing through surveys, especially colorectal cancer related with lynch syndrome (4%). |
| PubMedID- 23125224 | Cell cycle-related genes as modifiers of age of onset of colorectal cancer in lynch syndrome: a large-scale study in non-hispanic white patients. |
| PubMedID- 23896635 | Although variable, the lifetime risk of developing colorectal cancer (crc) in patients with lynch syndrome is approximately 80 %, with male carriers having a higher cumulative risk than female carriers [2]. |
| PubMedID- 25816162 | However, a higher frequency of mmr-dcf was observed in lynch syndrome patients with distal colorectal cancer localisation. |
| PubMedID- 21159521 | Perspectives for tailored chemoprevention and treatment of colorectal cancer in lynch syndrome. |
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